Phobia Lists

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A large number of-phobia lists circulate on the Internet, with words collected from indiscriminate sources, often copying each other. Also, a number of psychiatric websites exist that at the first glance cover a huge number of phobias, but in fact use a standard text to fit any phobia and reuse it for all unusual phobias by merely changing the name. Sometimes it leads to bizarre results, such as suggestions to cure "prostitute phobia".Such practice is known as content spamming and is used to attract search engines.

Psychological conditions:
In many cases specialists prefer to avoid the suffix -phobia and use more descriptive terms, see, e.g., personality disorders, anxiety disorders, avoidant personality disorder, love-shyness.

* Ablutophobia – fear of bathing, washing, or cleaning.
* Acrophobia, Altophobia – fear of heights.
* Agoraphobia, Agoraphobia Without History of Panic Disorder – fear of places or events where escape is impossible or when help is unavailable.
* Agraphobia – fear of sexual abuse.
* Aichmophobia – fear of sharp or pointed objects (as a needle, knife or a pointing finger).
* Algophobia – fear of pain.
* Agyrophobia – fear of crossing roads.
* Androphobia – fear of men.
* Anthropophobia – fear of people or being in a company, a form of social phobia.
* Anthophobia – fear of flowers.
* Aquaphobia, Hydrophobia – fear of water.
* Astraphobia, Astrapophobia, Brontophobia, Keraunophobia – fear of thunder, lightning and storms; especially common in young children.
* Autophobia – fear of being alone.
* Aviophobia, Aviatophobia – fear of flying.
* Bacillophobia, Bacteriophobia, Microbiophobia – fear of microbes and bacteria.
* Blood-injection-injury type phobia – a DSM-IV subtype of specific phobias
* Catoptrophobia - fear of mirrors or of one's own reflection.
* Cibophobia, Sitophobia – aversion to food, synonymous to Anorexia nervosa.
* Claustrophobia – fear of confined spaces.
* Coulrophobia – fear of clowns (not restricted to evil clowns).
* Decidophobia – fear of making decisions.
* Dental phobia, Dentophobia, Odontophobia – fear of dentists and dental procedures
* Dysmorphophobia, or body dysmorphic disorder – a phobic obsession with a real or imaginary body defect.
* Emetophobia – fear of vomiting.
* Ergasiophobia, Ergophobia – fear of work or functioning, or a surgeon's fear of operating.
* Ergophobia – fear of work or functioning.
* Erotophobia – fear of sexual love or sexual questions.
* Erythrophobia – pathological blushing.
* Gephyrophobia – fear of bridges.
* Genophobia, Coitophobia – fear of sexual intercourse.
* Gerascophobia – fear of growing old or ageing.
* Gerontophobia – fear of growing old, or a hatred or fear of the elderly.
* Glossophobia – fear of speaking in public or of trying to speak.
* Gymnophobia – fear of nudity.
* Gynophobia – fear of women.
* Haptephobia – fear of being touched.
* Heliophobia – fear of sunlight.
* Hemophobia, Haemophobia – fear of blood.
* Hexakosioihexekontahexaphobia – fear of the number 666.
* Hoplophobia – fear of weapons, specifically firearms (Generally a political term but the clinical phobia is also documented).
* Ligyrophobia – fear of loud noises.
* Lipophobia – fear/avoidance of fats in food.
* Mysophobia – fear of germs, contamination or dirt.
* Necrophobia – fear of death, the dead.
* Neophobia, Cainophobia, Cainotophobia, Cenophobia, Centophobia, Kainolophobia, Kainophobia – fear of newness, novelty.
* Nomophobia – fear of being out of mobile phone contact.
* Nosophobia – fear of contracting a disease.
* Nyctophobia, Achluophobia, Lygophobia, Scotophobia – fear of darkness.
* Osmophobia, Olfactophobia – fear of smells.
* Paraskavedekatriaphobia, Paraskevidekatriaphobia, Friggatriskaidekaphobia – fear of Friday the 13th.
* Panphobia – fear of everything or constantly afraid without knowing what is causing it.
* Pedophobia - fear/dislike of children
* Phasmophobia - fear of ghosts, spectres or phantasms.
* Phagophobia – fear of swallowing.
* Phobophobia – fear of having a phobia.
* Phonophobia – fear of loud sounds.
* Photophobia - fear of bright lights.
* Pyrophobia – fear of fire.
* Radiophobia – fear of radioactivity or X-rays.
* Sociophobia – fear of people or social situations
* Scopophobia – fear of being looked at or stared at.
* Somniphobia – fear of sleep.
* Spectrophobia – fear of mirrors and one's own reflections.
* Taphophobia – fear of the grave, or fear of being placed in a grave while still alive.
* Technophobia – fear of technology (see also Luddite).
* Tetraphobia – fear of the number 4.
* Tokophobia – fear of childbirth.
* Tomophobia – fear or anxiety of surgeries/surgical operations.
* Traumatophobia – a synonym for injury phobia, a fear of having an injury
* Triskaidekaphobia, Terdekaphobia – fear of the number 13.
* Trypanophobia, Belonephobia, Enetophobia – fear of needles or injections.
* Workplace phobia – fear of the work place.
* Xenophobia – fear of strangers, foreigners, or aliens.

Animal phobias:

* Ailurophobia – fear/dislike of cats
* Animal phobia - fear of certain animals, a category of specific phobias
* Apiphobia – fear/dislike of bees (also known as Melissophobia)
* Arachnophobia – fear/dislike of spiders
* Bufonophobia - fear/dislike of toads
* Cetaphobia - fear/dislike of whales
* Chiroptophobia – fear/dislike of bats
* Cynophobia – fear/dislike of dogs
* Entomophobia – fear/dislike of insects
* Equinophobia – fear/dislike of horses (also known as Hippophobia)
* Herpetophobia - fear/dislike of reptiles
* Ichthyophobia – fear/dislike of fish
* Leporiphobia - fear/dislike of rabbits
* Musophobia – fear/dislike of mice and/or rat
* Ophidiophobia – fear/dislike of snakes
* Ornithophobia – fear/dislike of birds
* Scoleciphobia – fear of worms
* Selachophobia - fear/dislike of sharks
* Taurophobia - fear/dislike of bulls
* Zoophobia – a generic term for animal phobias

Non-psychological conditions:

The following medical conditions have nothing to do with irrational fears. However, each usually has a psychological disorder of the same name which is an irrational fear. The behavior of an individual with the medical condition can be similar to the behavior of an individual with the psychological disorder of the same name (e.g., for both usages of Photophobia the person avoids light). The difference in usage is that for the medical term there is an underlying physiological condition that results in the behavior. For example, with medical Photophobia the hypersensitivity to light is sufficient such that at some light levels the person experiences pain which they avoid by seeking darkness. Removing the physiological cause of the hypersensitivity to light results in the person no longer avoiding light. With psychological Photophobia the person fears the light even though there is no current physiological pain caused by light.

* Hydrophobia – fear of water (a symptom of rabies).
* Photophobia – hypersensitivity to light causing aversion to light (a symptom of Meningitis and a common condition of migrane headaches).
* Phonophobia – hypersensitivity to sound causing aversion to sounds. Common during an alcohol hangover or migrane and in those with sensory disorders.
* Osmophobia – hypersensitivity to smells causing aversion to odors. Common during pregnancy.

Biology, chemistry:

Biologists use a number of -phobia/-phobic terms to describe predispositions by plants and animals against certain conditions. For antonyms, see here.

* Acidophobia/Acidophobic – preference for non-acidic conditions.
* Heliophobia/Heliophobic – aversion to sunlight.
* Hydrophobia/Hydrophobic – a property of being repelled by water.
* Lipophobicity – a property of fat rejection
* Ombrophobia – avoidance of rain
* Photophobia/Photophobic – a negative phototaxis or phototropism response.
* Superhydrophobe – the property given to materials that are extremely difficult to get wet.
* Thermophobia/Thermophobic – aversion to heat.
* Xerophobia/Xerophobic – aversion to dryness.

Prejudices and discrimination:
The suffix -phobia is used to coin terms that denote a particular anti-ethnic or anti-demographic sentiment, such as Europhobia, Francophobia, Hispanophobia, and Indophobia. Often a synonym with the prefix "anti-" already exists (e.g., Polonophobia vs. anti-Polonism). Anti-religious sentiments are expressed in terms such as Christianophobia and Islamophobia.

Other prejudices include:
* Biphobia – dislike of bisexuals
* Chemophobia – prejudice against artificial substances in favour of 'natural' substances.
* Ephebiphobia – fear/dislike of youth.
* Gerontophobia, Gerascophobia – fear of growing old or a hatred of the elderly.
* Heterophobia – fear/dislike of heterosexuals.
* Homophobia – aversion to homosexuality or fear of homosexuals. (This word has become a common political term, and many people interpret it as a slur.)
* Hoplophobia – aversion to firearms or firearms owners. This word has also gained a certain political notoriety as a dysphemism for "gun control advocate"
* Judeophobia – fear/dislike of Jews
* Lesbophobia – fear/dislike of lesbian women
* Pedophobia, Pediophobia – fear/dislike of children
* Psychophobia – fear/dislike of mentally ill
* Transphobia – fear or dislike of transgender or transsexual people.
* Xenophobia – fear or dislike of foreigners

Miscellaneous:
* Arachnophobia – "fear/dislike of spiders," a film
* Chromophobia – "hatred/fear of colors," a film
* Choreophobia – hatred of dance, a book by Anthony Shay about Iranian dance and its prohibition after the Iranian Revolution
* Entomophobia – a genus of orchids. The word means "fear of insects"
* Philophobia, an album by Arab Strap
* Robophobia – a novel by Richard Evans

Types Of Anxiety

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Varieties:

Existential anxiety:
Example: Angst, Existential crisis, and nihilism

Philosopher Søren Kierkegaard, in The Concept of Dread, described anxiety or dread associated with the "dizziness of freedom" and suggested the possibility for positive resolution of anxiety through the self-conscious exercise of responsibility and choosing.
Theologian Paul Tillich characterized existential anxiety as "the state in which a being is aware of its possible nonbeing" and he listed three categories for the nonbeing and resulting anxiety: ontic (fate and death), moral (guilt and condemnation), and spiritual (emptiness and meaninglessness). According to Tillich, the last of these three types of existential anxiety is predominant in modern times while the others were predominant in earlier periods. Tillich argues that this anxiety can be accepted as part of the human condition or it can be resisted but with negative consequences. In its pathological form, spiritual anxiety may tend to "drive the person toward the creation of certitude in systems of meaning which are supported by tradition and authority" even though such "undoubted certitude is not built on the rock of reality".
According to Viktor Frankl, author of Man's Search for Meaning, when faced with extreme mortal dangers the most basic of all human wishes is to find a meaning of life to combat the "trauma of nonbeing" as death is near.

Test anxiety:
Test anxiety is the uneasiness, apprehension, or nervousness felt by students who have a fear of failing an exam. Students suffering from test anxiety may experience any of the following: the association of grades with personal worth, fear of embarrassment by a teacher, fear of alienation from parents or friends, time pressures, or feeling a loss of control. Emotional, cognitive, behavioral, and physical components can all be present in test anxiety. Sweating, dizziness, headaches, racing heartbeats, nausea, fidgeting, and drumming on a desk are all common. An optimal level of arousal is necessary to best complete a task such as an exam; however, when the anxiety or level of arousal exceeds that optimum, it results in a decline in performance. Because test anxiety hinges on fear of negative evaluation, debate exists as to whether test anxiety is itself a unique anxiety disorder or whether it is a specific type of social phobia. In 2006, approximately 49%(need reference) of high school students were reportedly experiencing this condition. While the term "test anxiety" refers specifically to students, many adults share the same experience with regard to their career or profession. The fear of failing a task and being negatively evaluated for it can have a similarly negative effect on the adult.

Stranger and social anxiety:
Anxiety when meeting or interacting with unknown people is a common stage of development in young people. For others, it may persist into adulthood and become social anxiety or social phobia. "Stranger anxiety" in small children is not a phobia. Rather it is a developmentally appropriate fear by toddlers and preschool children of those who are not parents or family members. In adults, an excessive fear of other people is not a developmentally common stage; it is called social anxiety.
Trait anxiety:
Anxiety can be either a short term "state" or a long term "trait." Trait anxiety reflects a stable tendency to respond with state anxiety in the anticipation of threatening situations.It is closely related to the personality trait of neuroticism.

Anxiety in Positive psychology:
Anxiety in terms of challenge level and skill level.
In positive psychology, anxiety is described as a response to a difficult challenge for which the subject has low coping skills.

Anxiety

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Anxiety is a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry.
Definition:
1. Anxiety is a generalized mood condition that occurs without an identifiable triggering stimulus. As such, it is distinguished from fear, which occurs in the presence of an observed threat. Additionally, fear is related to the specific behaviors of escape and avoidance, whereas anxiety is the result of threats that are perceived to be uncontrollable or unavoidable.
2. Another view is that anxiety is "a future-oriented mood state in which one is ready or prepared to attempt to cope with upcoming negative events suggesting that it is a distinction between future vs. present dangers that divides anxiety and fear.
3. Anxiety is considered to be a normal reaction to stress. It may help a person to deal with a difficult situation, for example at work or at school, by prompting one to cope with it. When anxiety becomes excessive, it may fall under the classification of an anxiety disorder.
Symptoms:
Anxiety can be accompanied by physical effects such as heart palpitations, fatigue, nausea, chest pain, shortness of breath, stomach aches, or headaches. Physically, the body prepares the organism to deal with a threat. Blood pressure and heart rate are increased, sweating is increased, bloodflow to the major muscle groups is increased, and immune and digestive system functions are inhibited (the fight or flight response). External signs of anxiety may include pale skin, sweating, trembling, and pupillary dilation. Someone suffering from anxiety might also experience it as a sense of dread or panic.
Although panic attacks are not experienced by every anxiety sufferer, they are a common symptom. Panic attacks usually come without warning, and although the fear is generally irrational, the perception of danger is very real. A person experiencing a panic attack will often feel as if he or she is about to die or pass out. Panic attacks may be confused with heart attacks.
Anxiety does not only consist of physical symptoms. There are many emotional symptoms involved as well. Some of them include: "Feelings of apprehension or dread, trouble concentrating, feeling tense or jumpy, anticipating the worst, irritability, restlessness, watching (and waiting) for signs (and occurrences) or danger, and, feeling like your mind's gone blank.There's also, "nightmares/bad dreams, obsessions about sensations, deja vu, a trapped in your mind feeling, and feeling like everything is scary.
One of the most common symptoms of anxiety is fear, which includes the fear of dying. "You may...fear that the chest pains [a physical symptom of anxiety] are a deadly heart attack or that the shooting pains in your head [another physical symptom of anxiety] are the result of a tumor or aneurysm. You feel an intense fear when you think of dying, or you may think of it more often than normal, or can’t get it out of your mind.
Biological basis:
Neural circuitry involving the amygdala and hippocampus is thought to underlie anxiety[8]. When confronted with unpleasant and potentially harmful stimuli such as foul odors or tastes, PET-scans show increased bloodflow in the amygdala.[9][10] In these studies, the participants also reported moderate anxiety. This might indicate that anxiety is a protective mechanism designed to prevent the organism from engaging in potentially harmful behaviors.
Although single genes have little effect on complex traits and interact heavily both between themselves and with the external factors, research is underway to unravel possible molecular mechanisms underlying anxiety and comorbid conditions.
Clinical Scales:
The HAM-A (Hamilton Anxiety Scale) is a widely used interview scale that measures the severity of a patient's anxiety, based on 14 parameters, including anxious mood, tension, fears, insomnia, somatic complaints and behavior at the interview. Developed by M. Hamilton in 1959, the scale predates the current definition of generalized anxiety disorder (GAD). However, it covers many of the features of GAD and can be helpful in assessing its severity.

Ascites-The Cancer Symptom

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Inside the abdomen is a membrane called the peritoneum, which has two layers. One layer lines the abdominal wall and the other layer covers the organs inside the abdominal cavity. The peritoneum produces a fluid that acts as a lubricant and allows the abdominal organs to glide smoothly over one another. Sometimes too much of this fluid can build up between the two layers and this is called ascites.It is one of the symptom of the dangerous Cancer.
Causes of ascites:
Ascites can be a symptom of many types of cancer. The types of cancer that are more likely to cause ascites are cancer of the breast, lung, large bowel (colon), stomach, pancreas, ovary and the lining of the womb (endometrium).
There may be several reasons for the build-up of ascites:
* If cancer cells have spread to the lining of the abdomen, they can irritate it and cause fluid to build up.
* If the liver is affected by cancer cells, this may block the circulation of blood through the liver, which can lead to a build-up of fluid in the abdomen.
* If the liver is damaged, it may produce less blood protein. This may upset the body's fluid balance, which causes fluid to build up in the body tissues, including the abdomen.
* Cancer cells can block the lymphatic system. The lymphatic system is a network of fine channels which runs throughout the body. One of its functions is to drain off excess fluid, which is eventually got rid of in the urine. If some of these lymphatic channels are blocked, the system cannot drain efficiently and fluid can build up.
Symptoms:
The symptoms of ascites can be very distressing. The abdomen becomes very swollen and distended, which can be uncomfortable or painful. It can also cause difficulty in getting comfortable, sitting up or walking. It can make you feel very tired (lethargic) and breathless. It may cause feelings of sickness (nausea) or make throw up (vomiting). You may also suffer indigestion and a reduced appetite.
Ascitic drainage:
In order to relieve symptoms, the treatment of ascites involves slowing the build-up of the fluid and putting a tube into the abdomen to drain it (known as paracentesis).
The ascitic tube (drain) is usually inserted by a doctor and the procedure can be done in the ward or in the outpatients clinic. Sometimes the drain is put in while you are having an ultrasound scan which helps guide the doctor where to position the drain.
Once you're lying down comfortably the skin in the area where the drain is to be inserted is cleaned. The doctor will then give you an injection of local anaesthetic to numb the area and prevent the procedure from being painful.

The doctor makes a very small cut in the skin of the abdomen and inserts a thin tube called a cannula. The cannula is attached to a tube and drainage bag. The ascitic fluid drains out of the abdomen and collects inside the drainage bag. The cannula may be held in place with a couple of stitches and covered with a dressing.
The length of time that the drainage tube needs to stay in place depends on the amount of fluid that needs to be drained off. Sometimes a small amount of fluid can be drained in the outpatients clinic. If there is a large amount of fluid however, the procedure may need to be carried out in hospital under the supervision of the doctors and nurses, and the drain may stay in place for a period of 2–3 days.
It is possible for the ascites to build up again and drainage may need to be carried out more than once.
Possible problems with ascitic drainage:
Usually the fluid will be drained off slowly, as a sudden release of pressure in the abdomen can cause a drop in blood pressure. A litre of fluid may be drained safely as soon as the drain has been inserted. After this, the drainage will usually be done more slowly. Your blood pressure will be checked during the procedure.
The ascitic drain can become blocked. This can sometimes be cleared by changing your position or sitting upright. Occasionally the tube may need to be replaced.
The drain can sometimes become infected and you will have your temperature taken regularly as a high temperature can be a sign of infection.
When the drain has been removed there may be a leakage of fluid from the drain site, until the hole heals. The hole will be stitched together and the site will need to be covered with a dressing or drainage bag until the leakage has stopped. Usually the stitches are taken out after about a week.
Other methods of dealing with ascites:
The doctors may prescribe a water tablet (diuretic) called spironolactone (Aldactone®). This can make you want to pass more urine than normal but will slow the build-up of the ascitic fluid.
A peritoneo-venous shunt (sometimes called a LeVeen shunt) may be considered. A shunt is a plastic or silicone rubber tube that is placed into the peritoneal cavity and drains the ascitic fluid directly into a large vein. This is a more complicated procedure and usually needs to be done under a general anaesthetic. You will also need intensive monitoring for the first 24–48 hours, in a high dependency unit at the hospital, in order to check that the shunt is working properly. The shunt stays in permanently.

Athlet's Foot-The Fungal Infection

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The feet are the most common area infected by certain fungi called dermatophytes, causing tinea pedis or athlete’s foot. Athlete’s foot is a very common problem experienced by up to 70% of the population at some time in their life.
Athlete’s Foot Demographics:
Athlete’s foot is common in adult males, but uncommon in women. Athlete’s foot can also affect children before puberty, regardless of sex. Athlete’s foot seems to occur most often in people who have some characteristic of their immune system which predisposes them to infections regardless of the precautions they take to prevent infection. Once an infection is established, the person becomes a carrier and is more susceptible to recurrences and complications.
Athlete’s Foot Types:
Athlete’s foot is divided into three categories:
1.Chronic interdigital athlete’s foot
2.Chronic scaly athlete’s foot (moccasin type)
3.Acute vesicular athlete’s foot
4.Chronic Interdigital Athlete’s Foot
This is the most common type of athlete’s foot. It is characterized by scaling, maceration, and fissures most commonly in the web space between the 4th and 5th toes. Tight-fitting, non-porous shoes compress the toes, creating a warm, moist environment in the web spaces. Many times the infecting fungus interacts with bacteria causing a more severe infection that extends onto the foot. With this type of athlete’s foot, itching is typically most intense when the socks and shoes are removed.
Moccasin Type Athlete’s Foot:
This type of athlete’s foot, also known as moccasin-type, is caused by Trichophyton rubrum. This dermatophyte causes dry, scaling skin on the sole of the foot. The scale is very fine, and silvery, and the skin underneath is usually pink and tender. The hands may also be infected, although the usual pattern of infection is two feet and one hand, or one foot and two hands. This type of athlete’s foot is often seen in people with eczema or asthma. It is associated with fungal nail infections which may lead to recurrent skin infections.
Acute Vesicular Athlete’s Foot:
This is the least common type of athlete’s foot, caused by Trichophyton mentagrophytes. It often originates in people who have a chronic interdigital toe web infection. This type of athlete’s foot is characterized by the sudden onset of painful blisters on the sole or top of the foot. Another wave of blisters may follow the first and may also involve remote sites of the body such as the arms, chest, or sides of the fingers. These blisters are caused by an allergic reaction to the fungus on the foot and are known as an id reaction. This type of athlete’s foot is also known as “jungle rot,” a historically disabling problem for servicemen fighting in warm, moist, humid conditions.
Diagnosis of Athlete’s Foot:
Athlete’s foot is diagnosed by clinical exam and performing a KOH test. A positive KOH test confirms the diagnosis, but a negative KOH test does not mean a person does not have athlete’s foot. Fungal elements can be difficult to isolate in interdigital and moccasin type athlete’s foot.
Treatment of Athlete’s Foot:
Mild cases of athlete’s foot, especially interdigital toe web infections, can be treated with topical antifungal creams or sprays such as tolnaftate, or lotrimin. Topical medications should be applied twice a day until the rash is completely resolved. More serious infections and moccasin type athlete’s foot should be treated with oral antifungal medications such as terbinafine or itraconazole for 2 to 6 months. All oral antifungal medications can affect the liver; therefore, blood tests should be performed monthly to evaluate liver function.

Ringwarm-The Fungal Infection

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Ringworm, known in medical terms as tinea corporis, is actually not caused by a worm, but by a fungus. Tinea corporis refers to a fungal infection of the body or face, not including the beard area onmen. Ringworm occurs more commonly in warm, tropical environments, affects men and women equally, and affects all ages equally.

Ringworm - Superficial Fungus Infection:
Ringworm is a dermatophyte infection. Dermatophytes are a group of related fungi that infect and survive on dead ke

ratin, the top layer of the epidermis.
The following are the most common fungi responsible for ringworm:
#Trichophyton rubrum
#Microsporum canis
#Trichophyton mentagrophytes
Ringworm - Appearance:
The most common appearance of ringworm is a lesion that starts as a flat, scaly spot which then develops a raised border that advances outward in a circle. The advancing border is red, raised, and scaly while the central area is more normal appearing, usually still with fine scaling. Some ringworm infections, especially those treated with a steroid like hydrocortisone, can have vesicles or pustules in the advancing border or in the center.
Ringworm - Diagnosis:
Ringworm is sometimes diagnosed clinically, based on the appearance of the classic rash. However, some ringworm infections can mimic other skin conditions such as granuloma annulare, nummular eczema, or tinea versicolor. The easiest method used to confirm the diagnosis of ringworm is a KOH test. Rarely, fungal cultures are taken to identify the exact fungus causing the infection.
Ringworm - Topical Treatment:
In general ringworm responds well to topical treatment. Topical antifungals are applied to the lesion twice a day for at least 3 weeks. The lesion usually resolves within 2 weeks, but therapy should be continued for another week to insure the fungus is completely eradicated. The most commonly used antifungal creams are:
Miconazole (Monistat)
Clotrimazole (Mycelex)
Ketoconazole (Nizoral)
Terbinafine (Lamisil)
Ringworm - Oral Treatment:
If there are several ringworm lesions or if the lesions are extensive, oral antifungal medications can be used. Oral medications are taken once a day for 7 days and result in a 100% clinical cure rate. The recommended oral antifungal medications are:
Terbinafine (Lamisil) 250 mg
Itraconazole (Sporanox) 200 mg
Preventing Ringworm:
Because fungi prefer warm, moist environments, preventing ringworm involves keeping skin dry and avoiding contact with infectious material. Basic prevention measures include:
#Wash hands after handling animals, soil, and plants
#Avoid touching characteristic lesions on other people
#Wear loose-fitting clothing
#Practice good hygiene when participation in sports involves physical contact with other people

Tinea Versicolor-The Fungal Infection

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Tinea versicolor, also known as pityriasis versicolor, is a superficial fungal infection of the skin that is often confused with other common rashes.
Cause of Tinea Versicolor:
The yeasts, Pityrosporum orbiculare and Pityrosporum ovale, are a part of the normal skin flora. They reside in the stratum corneum and hair follicles and have an affinity for oil glands. Certain factors can cause these yeasts can convert to a pathogenic form known as Malassezia furfur, which causes the rash of tinea versicolor. Some of these
predisposing factors include:

Removal of the adrenal gland
Cushing's disease
Pregnancy
Malnutrition
Burns
Steroid therapy
Suppressed immune system
Oral contraceptives
Excess heat
Excess humidity
Who Gets Tinea Versicolor:
Tinea versicolor can occur at any age, but is most common in adolescence and early adulthood, a time when the sebaceous glands are more active. It is also more common in tropical and semi-tropical climates. Tinea versicolor has a recurrence rate of 80% after 2 years.
Appearance of Tinea Versicolor:
The rash of tinea versicolor is a hypopigmented, hyperpigmented, or red flat eruption that may coalesce into large patches with an adherent fine scale. This rash occurs mainly on the trunk, but can also occur on the extremities. Hypopigmentation occurs because the yeast produces a chemical that turns off the melanocytes, resulting in decreased melanin production. The hyperpigmentation or redness occur as a result of the inflammatory response in the skin.
Diagnosis of Tinea Versicolor:
Tinea versicolor can be diagnosed by three different tests:

1.A KOH test shows a characteristic "spaghetti and meatballs" appearance under the microscope.
2.Under a Wood's light examination, the yeast fluoresces pale yellow.
3.A fungal culture can be performed after adding oil to the culture medium, but it is rarely necessary.
Rashes that Look Like Tinea Versicolor
The following rashes can be confused with tinea versicolor:
Vitiligo
Pityriasis alba
Seborrheic Dermatitis
Syphilis
Pityriasis Rosea
Nummular eczema
Guttate psoriasis
Treatment of Tinea Versicolor:
There are a number of different medications used to treat tinea versicolor. Because the yeast inhabits the top layer of the skin, topical antifungal medications are very effective. If the rash is extensive, oral antifungal medications may be needed. It is important to note that even though the pathogenic yeast has been eradicated after treatment, the hypopigmentation may persist for weeks until the melanocytes start to produce melanin again. Because this rash has a high recurrence rate, medication may be needed periodically to prevent recurrence.

Tinea versicolor is a rash that occurs after the normal skin yeasts, Pityrosporum orbiculare or Pityrosporum ovale, transform to a pathogenic form and turn off melanin-producing cells in the skin. Because the yeast inhabits the top layer of the skin, topical antifungal medications are very effective. If the rash is extensive, oral antifungal medications may be needed. Because tinea versicolor has a recurrence rate of 80% after 2 years, periodic use of medications may be needed to suppress the rash.

Treatment of Tinea Versicolor with Topical Antifungals:
Topical antifungal medications are the treatment of choice for tinea versicolor. The following topical antifungal treatment regimens have been shown to produce a greater than 70% clinical response rate:
2% Ketoconazole cream applied once daily for 11-22 days
2% Ketoconazole shampoo regimen (lathered over affected and surrounding areas and left on for at least 5 minutes before rinsing) applied once daily for 3 consecutive days
1% Terbinafine solution applied twice daily for 1 week
1% Clotrimazole solution applied once daily for 1 week
Treatment of Tinea Versicolor with Oral Antifungals
Oral antifungal medications can cause side effects such as nausea or reversible liver damage, but these side effects are not common with the short courses of therapy used for tinea versicolor. Oral griseofulvin and oral terbinafine are not effective treatments for tinea versicolor.
The following oral treatment regimens have been shown to produce a greater than 70% clinical response rate:
Itraconazole 200mg every other day for 7 days
Ketoconazole 400mg single dose
Fluconazole 400mg single dose
Fluconazole 150mg or 300mg weekly for 4 weeks
Treatment of Tinea Versicolor with Dandruff Shampoos
Until recently, dandruff shampoos were the mainstay of treatment for tinea versicolor. They are less effective than the antifungal medications and can cause skin irritation, but they are available over the counter and are less expensive.
The following regimens have been shown to be effective:
Sulfur-salicyclic acid shampoo applied nightly as a lotion for 1 week
Zinc-pyrithione shampoo regimen (applied daily as a lotion and left on for 5 minutes before rinsing) for 2 weeks
Selenium sulfide 2.5% lotion regimen (applied daily as a lotion and left on for 10 minutes before rinsing) for 1 week

Different Mycosis

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Mycosis (plural: mycoses) is a condition in which fungi pass the resistance barriers of the human or animal body and establish infections.
Classification:
Mycoses are classified according to the tissue levels initially colonized:
Superficial mycoses:
Superficial mycoses - limited to the outermost layers of the skin and hair.
An example of a fungal infection is:
Tinea versicolor: Tinea versicolor is a fungus infection that commonly affects the skin of young people, especially the chest, back, and upper arms and legs. Tinea versicolor is caused by a fungus that lives in the skin of almost all adults. It doesn't usually affect the face. This fungus produces spots that are either lighter than the skin or a reddish-brown. This fungus exists in two forms, one of them causing visible spots. Factors that can cause the fungus to become more visible include high humidity, as well as immune or hormone abnormalities. However, almost all people with this very common condition are healthy. The causative agent is lipophilic,yeast like fungus Pityrossporum orbiculare(Malassezia furfur)
Cutaneous mycoses:
Cutaneous mycoses - extend deeper into the epidermis, as well as invasive hair and nail diseases. These diseases are restricted to the keratinized layers of the skin, hair, and nails. Unlike the superficial mycoses, host immune responses may be evoked, resulting in pathologic changes expressed in the deeper layers of the skin. The organisms that cause these diseases are called dermatophytes. The resulting diseases are often called ringworm (even though there is no worm involved) or tinea. Cutaneous mycoses are caused by Microsporum, Trichophyton, and Epidermophyton fungi, which together comprise 41 species.
Subcutaneous mycoses:
Subcutaneous mycoses - involve the dermis, subcutaneous tissues, muscle, and fascia. These infections are chronic and can be initiated by piercing trauma to the skin, which allows the fungi to enter. These infections are difficult to treat and may require surgical interventions such as debridement.
Systemic mycoses due to primary pathogens:
Systemic mycoses due to primary pathogens - originate primarily in the lungs and may spread to many organ systems. Organisms that cause systemic mycoses are inherently virulent. Generally, primary pathogens that cause systemic mycoses are dimorphic.
[edit]Systemic mycoses due to opportunistic pathogens
Systemic mycoses due to opportunistic pathogens - infections of patients with immune deficiencies who would otherwise not be infected. Examples of immunocompromised conditions include AIDS, alteration of normal flora by antibiotics, immunosuppressive therapy, and metastatic cancer. Examples of opportunistic mycoses include Candidiasis, Cryptococcosis and Aspergillosis.
Treatment:
Antifungal drugs are used to treat mycoses. Depending on the nature of the infection, a topical or systemic agent may be used. Photochemotherapy or photopheresis is a technique used at major medical centers for the treatment of mycosis fungoides.
Prevention:
Keeping the skin clean and dry, as well as maintaining good hygiene, will help larger topical mycoses. Because fungal infections are contagious, it is important to wash after touching other people or animals. Sports clothing should also be washed after use. Wearing flip-flops if using a community swimming pool or shower will also help prevent topical infections

Anti Fungal Drugs

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Mode of action

Antifungals work by exploiting differences between mammalian and fungal cells to kill the fungal organism without dangerous effects on the host. Unlike bacteria, both fungi and humans are eukaryotes. Thus fungal and human cells are similar at the molecular level. This makes it more difficult to find or design drugs that target fungi without affecting human cells. Consequently, many antifungal drugs cause side-effects. Some of these side-effects can be life-threatening if the drugs are not used properly.

Classes

Polyene antifungals

A polyene is a molecule with multiple conjugated double bonds. A polyene antifungal is a macrocyclic polyene with a heavily hydroxylated region on the ring opposite the conjugated system. This makes polyene antifungals amphiphilic. The polyene antimycotics bind with sterols in the fungal cell membrane, principally ergosterol. This changes the transition temperature (Tg) of the cell membrane, thereby placing the membrane in a less fluid, more crystalline state. As a result, the cell's contents leak and the cell dies. Animal cells contain cholesterol instead of ergosterol and so they are much less susceptible. As a polyene's hydrophobic chain is shortened, its sterol binding activity is increased. Therefore, further reduction of the hydrophobic chain may result in it binding to cholesterol, making it toxic to animals.

§ Natamycin – 33 Carbons, binds well to ergosterol

§ Rimocidin

§ Filipin – 35 Carbons, binds to cholesterol (toxic)

§ Nystatin

§ Amphotericin B

§ Candicin

Imidazole, triazole, and thiazole antifungals

The imidazole and triazole drugs are synthetic antifungal drugs that inhibit the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell membrane synthesis. These drugs also block steroid synthesis in humans.

Imidazoles

§ Miconazole – miconazole nitrate

§ Ketoconazole

§ Clotrimazole – marketed as Lotrimin or Lotrimin AF (and Canesten in the UK)

§ Econazole

§ Bifonazole

§ Butoconazole

§ Fenticonazole

§ Isoconazole

§ Oxiconazole

§ Sertaconazole – marketed as Ertaczo in North America

§ Sulconazole

§ Tioconazole

The triazoles are newer, less toxic[citation needed] and more effective[citation needed]:

Triazoles

§ Fluconazole

§ Itraconazole

§ Isavuconazole

§ Ravuconazole

§ Posaconazole

§ Voriconazole

§ Terconazole

Thiazoles

§ Abafungin

Allylamines

Allylamines inhibit squalene epoxidase, another enzyme required for ergosterol synthesis:

§ Terbinafine – marketed as "Lamisil" in North America, Australia, the UK, Germany and the Netherlands

§ Amorolfine

§ Naftifine – marketed as "Naftin" in North America

§ Butenafine – marketed as Lotrimin Ultra

Echinocandins

Echinocandins inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-β glucan synthase:

§ Anidulafungin

§ Caspofungin

§ Micafungin

Others

§ Benzoic acid – has antifugal properties but must be combined with a keratolytic agent such as in Whitfield's Ointment

§ Ciclopirox – (ciclopirox olamine), most useful against Tinea versicolour

§ Tolnaftate – marketed as Tinactin, Desenex, Aftate, or other names

§ Undecylenic acid – an unsaturated fatty acid derived from natural castor oil; fungistatic as well as anti-bacterial and anti-viral

§ Flucytosine or 5-fluorocytosine – an antimetabolite

§ Griseofulvin – binds to polymerized microtubules and inhibits fungal mitosis

§ Haloprogin – discontinued due to the emergence of more modern antifungals with fewer side effects

§ Sodium bicarbonate (NaHCO3)

Alternatives

§ Allicin – created from crushing garlic

§ Tea tree oil – ISO 4730 ("Oil of Melaleuca, Terpinen-4-ol type")

§ Citronella oil

§ Iodine – Lugols Solution

§ lemon grass

§ olive leaf

§ orange oil

§ palmarosa oil

§ patchouli

§ lemon myrtle

§ Neem Seed Oil

§ Coconut Oil – medium chain triglycerides in the oil have antifungal activities

§ Zinc – in dietary supplements or natural food sources, including pumpkin seeds and chick peas

§ Selenium – in dietary supplements or natural food sources, particularly Brazil nuts

Anti-dandruff shampoos

Antifungal drugs (such as ketoconazole) are often found in anti-dandruff shampoos. The antifungal drugs inhibit the yeast Malassezia globosa which encourages seborrhoeic dermatitis and tinea versicolor.

Active ingredient

Example of product

Comments

Sodium bicarbonate (baking soda)

Arm & Hammer

Ketoconazole[8]

Nizoral, or Fungoral

There is a claim that Nizoral shampoo has hair loss benefits but Nizoral Shampoo does not have FDA approval as a hair loss remedy

Ciclopirox olamine

Loprox

Has similar efficacy to ketoconazole with a relative increase in subjective symptom relief due to its inherent anti-inflammatory properties

Piroctone olamine(Octopirox)

Nivea Complete Control

A replacement for the commonly used compound zinc pyrithione.

Zinc pyrithione

Head & Shoulders, Johnson and Johnson ZP-11, Clinic All Clear, Pantene Pro V, Sikkai Powder

An antifungal and antibacterial agent first reported in the 1930s.

Selenium sulfide

Selsun Blue, Vichy Dercos Anti-Dandruff shampoo, other varieties of Head & Shoulders

In the United States, 1% strength is available over-the-counter, and a 2.5% strength is also available with aprescription.

Tar

Neutrogena T/Gel

Tea tree oil